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肠道菌群中特定益生菌株对溃疡性结肠炎患者黏膜愈合及免疫调节的机制研究

作者:乔博玺

院校:贵州医科大学(贵州 贵阳 550004)

摘要:本研究聚焦肠道菌群中特定益生菌株对溃疡性结肠炎(UC)患者黏膜愈合及免疫调节的机制。通过体外细胞实验、动物实验及临床研究展开探索。体外实验表明,特定益生菌株可提升结肠上皮细胞 PCNA 表达、抑制细胞凋亡相关通路、增强紧密
连接蛋白表达,促进黏膜修复。动物实验发现,该益生菌株能调节肠道局部免疫细胞亚群,如促进巨噬细胞 M2 型极化、调节树突状细胞功能与 T 细胞亚群平衡,减少炎症因子分泌、增加抗炎因子产生,减轻肠道炎症。临床研究显示,益生菌治疗组在黏膜愈合指标(内镜评分与组织病理学评分)、免疫指标(外周血免疫细胞亚群与炎症因子水平)及临床症状与生活质量方面均有显著改善。综合而言,特定益生菌株对 UC 治疗具有多途径作用机制,黏膜愈合与免疫调节协同关联,在 UC 治疗中有潜在应用价值,但研究存在一定局限性,未来需进一步深入探究。

关键词

特定益生菌株;溃疡性结肠炎;黏膜愈合;免疫调节;作用机制

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参考

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