The mechanism by which exosomes derived from bone marrow mesenchymal stem cells promote the regeneration of renal tubules in acute kidney injury through the regulation of the PTEN signaling pathway by miR-21

作者：Jin Yu

院校：Changzhi Medical College, Shanxi Changzhi, 046000

摘要：Acute kidney injury (AKI) is a significant global health issue with limited current treatment options. This study focused on the mechanism by which exosomes derived from bone marrow mesenchymal stem cells (BMSCs) promote renal tubule regeneration in AKI through the regulation of the PTEN signaling pathway by miR-21. BMSCs were isolated and characterized, and their exosomes were purified. In vitro, renal tubular epithelial cell injury models were established, and the co-culture of exosomes and cells demonstrated enhanced cell proliferation and reduced apoptosis. In vivo, AKI animal models showed improved renal function and histopathological changes after exosome treatment. miR-21 was found to be upregulated in exosomes and recipient cells, targeting PTEN and activating the PI3K/AKT pathway. The signaling network also interacted with other pathways related to renal tubule regeneration. The study highlights the potential of exosome therapy for AKI and provides insights into the underlying molecular mechanisms, although further research is needed to address remaining
challenges and translate these findings into clinical applications.

关键词

Acute kidney injury; Bone marrow mesenchymal stem cells; Exosomes; miR-21; PTEN signaling pathway; Renal tubule regeneration

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The mechanism by which exosomes derived from bone marrow mesenchymal stem cells promote the regeneration of renal tubules in acute kidney injury through the regulation of the PTEN signaling pathway by miR-21

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